基于细胞衰老探讨中医药治疗糖尿病周围神经病变的研究进展OA

Diabetic Peripheral Neuropathy(DPN)is one of the most common and harmful complications of type 2 diabetes.DPN's pathogenesis include high blood sugar-induced oxidative stress,inflammation,and mitochondrial dysfunction.These factors are combined to damage nerve fibers,leading to sensory issues,pain,and numbness.Through a coordinated effect,these factors trigger nerve fiber damage and lead to sensory abnormalities,pain and numbness in limbs,and other symptoms,seriously restricting patients' activities of daily living and mobility.Recent research highlights that cellular senescence plays a critical role in DPN.Cellular senescence is manifested by the loss of cell proliferation ability,and further aggravates nerve damage via oxidative stress,mitochondrial dysfunction,autophagy impairment,inflammatory reaction,and other mechanisms,accelerating DPN occurrence and progression.In terms of medical treatment,current methods focus on blood sugar control,pain relief medicine,and microcirculation improvement,while no therapy has been developed based on cellular senescence.In contrast,traditional Chinese medicine(TCM)shows a unique advantage in DPN prevention and treatment via cellular senescence modulation.TCM emphasizes a holistic approach,as well as syndrome differentiation and treatment,effective in anti-aging and nerve damage repair.Recent studies show that TCM active ingredients,including puerarin,ginsenosides,and berberine,can reduce inflammation,oxidative stress,and apoptosis via signaling pathway regulation,thereby slowing cellular senescence to alleviate nerve damage.Furthermore,TCM compounds such as Buyang Huanwutang,Taohong Siwutang,and Huangqi Guizhi Wuwutang exert synergistic effects on cellular senescence-related pathways to improve nerve health and reduce DPN clinical symptoms.Therefore,this paper reviews the literature related to the interaction between cellular senescence and DPN from the perspective of cellular senescence,summarizing the mechanism of DPN and TCM intervention strategies.