太原地区HBsAg-/HBV DNA+献血者乙肝病毒感染特征分析OA

Objective To analyze characteristics of hepatitis B infection in HBsAg-/HBV DNA+blood donors in Taiyuan,so as to provide evidence for adjusting blood screening strategies.Methods Blood samples of HBsAg-/HBV DNA+donors were tested using enzyme-linked immunosorbent assay(ELISA),chemiluminescence assay,nucleic acid qualita-tive test,and nucleic acid quantitative test.Data on HBsAg-/HBV DNA+donors in Taiyuan region from January 1,2016 to December 31,2024 were statistically analyzed to evaluate the detection rate,demographic characteristics,influencing fac-tors of detection rate,nucleic acid quantitative results,and serological patterns of HBsAg-/HBV DNA+donors.Results From January 1,2016 to December 31,2024,991 565 donor samples underwent nucleic acid testing in Taiyuan.A total of 309 HBsAg-/HBV DNA+samples were detected,resulting in an HBsAg-/HBV DNA+detection rate of 3.12 per 10 000.The detection rate varied significantly across different years(P<0.05).Males had a significantly higher HBsAg-/HBV DNA+detection rate than females,first-time donors had a higher rate than repeat donors,and whole blood donors had a higher rate than apheresis donors(P<0.05).The detection rate also differed significantly among age groups(P<0.05).Logistic regression analysis showed that gender,age,donation frequency,and donation type were all influencing factors for HBsAg-/HBV DNA+detection(all P<0.05).The predominant serological patterns among HBsAg-/HBV DNA+donors were HBsAb+/HBcAb+(43.69%,135/309)or HBcAb+alone(24.27%,75/309).Viral load was detectable in 53.40%(165/309)of the HBsAg-/HBV DNA+donors.Among these,61.21%(101/165)donors had a viral load<20 IU/mL,and 94.55%(156/165)had a viral load<200 IU/mL.Donors with viral load<200 IU/mL primarily exhibited HBsAb+/HBcAb+(41.67%,65/156)or HBcAb+alone(36.54%,57/156)serological patterns.Conclusion The prevalence of HBsAg-/HBV DNA+is low among blood donors in Taiyuan.Higher detection rates were observed in the 46-55 years age group,males,first-time donors,and whole blood donors.HBsAg-/HBV DNA+donors exhibit specific sero-logical patterns and generally have low viral loads,indicating a potential residual transfusion risk.It is recommended to add HBcAb testing,together with high-sensitivity nucleic acid testing technologies and donor follow-up,to ensure blood safety and guide donor reentry.