深圳地区献血者年龄与献血不良反应相关性的回顾性队列分析OA

Objective To statistically analyze the association between blood donor age and the incidence of adverse re-actions based on whole blood donor data from Shenzhen.Methods Data on basic characteristics and records of adverse do-nation reactions among voluntary whole blood donors in Shenzhen from January 2017 to June 2025 were extracted.A total of 795 404 whole blood donations were recorded,including 502 743 from males and 292 661 from females,with 1 088 and 751 cases of adverse reactions,respectively.Analyses were performed using R software,including restricted cubic spline(RCS)analysis,binary logistic regression,and generalized estimating equations(GEE)to evaluate the correlation between donor age and adverse reactions.Results A total of 1 839 cases of adverse reactions were recorded,accounting for 0.23%of the total donations.Both binary logistic regression and GEE model revealed that,compared with the≤55 years age group,the incidence of adverse reactions was reduced in both male and female donors in the>55 years age group,with the difference being statistically significant in males.Using the<23 years age group as a reference,the incidence of adverse reactions sig-nificantly decreased in both male and female donors across the 23-30,31-40,41-50,and 51-60 age groups,with the differences being statistically significant.Conclusion There is a negative correlation between the rate of adverse donation reactions and age,with the incidence of such reactions among whole blood donors over 55 years old being no higher than that among donors aged 55 years or younger.These findings carry positive significance for safeguarding the donation rights of ol-der donors and meeting clinical blood demand.