基于PI3K/Akt信号通路探讨中医药治疗食管癌的研究进展OA

Esophageal cancer(EC)is a highly prevalent malignant tumor in China.The phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway,as one of the key oncogenic pathways,can promote the cell cycle progression,proliferation,migration,and invasion,induce chemoresistance,and inhibit apoptosis and autophagy of EC cells.Traditional Chinese medicine(TCM),with the advantages of targeting multiple points with multiple components to delay cancer progression,can target the PI3K/Akt signaling pathway for EC treatment.This article preliminarily discusses the molecular mechanism and role of the PI3K/Akt signaling pathway in EC and elaborates on the specific targets and efficacy of TCM in treating EC through intervention in the PI3K/Akt signaling pathway in the past five years.TCM materials and extracts inhibiting the PI3K/Akt signaling pathway in EC include Borneolum,spore powder of Ganoderma lucidum without spore coat,extract of Celastrus orbiculatus,root extract of Taraxacum,and Bruceae Fructus oil emulsion.TCM active ingredients exerting the effect include flavonoids,terpenoids,saponins,phenols,polysaccharides,alkaloids,and other compounds.TCM compound prescriptions with such effect include Qige San,Huqi San,Xuanfu Daizhetang,Tongyoutang and its decomposed prescriptions,Liujunzi Tang,and Xishenzhi Formula.In addition,TCM injections such as Compound Kushen Injection and Kang'ai injection also inhibit the PI3K/Akt signaling pathway in EC.This paper summarizes the role of the PI3K/Akt signaling pathway in EC and the TCM interventions,aiming to provide reference for the research and clinical application of new drugs for EC.