基于功能性近红外光谱成像的卒中后焦虑患者前额叶皮质激活特征及机制研究OA

Objective To observe the activation patterns and functional connectivity in the prefrontal cortex of patients with post-stroke anxiety(PSA)using functional near-infrared spectroscopy,in order to explore the underlying neural mech-anism. Methods From December,2024 to September,2025,120 stroke patients were selected in Changzhou De'an Hospital.They were divided into PSA group(n=60)and non-PSA group(n=60)according to the score of Hamilton Anxi-ety Scale(HAMA).All patients wore an 18-channel fNIRS acquisition cap for detection.The differences in rest-ing-state functional connectivity between the frontopolar cortex(FPC)and dorsolateral prefrontal cortex(DLP-FC)were examined in both groups,as well as task-related activation in these brain regions. Results Resting-state functional connectivity analysis revealed no statistically significant difference in network connec-tivity between two groups in the FPC and DLPFC regions(|t|<1.301,P>0.05).Task-related activation results revealed significantly reduced activation in the contralateral FPC of PSA group compared to the non-PSA group(Z=-2.063,P<0.05).Activation levels in this region showed a negative correlation with the scores of HAMA(ρ=-0.201,P=0.028). Conclusion Activation decreased in the contralateral frontal pole during the task state for patients with PSA,and the acti-vation levels negatively correlates with anxiety severities.