急性轻型非致残性缺血性脑卒中患者血压变异性与早期神经功能恶化的相关性分析OA
Association between blood pressure variability and early neurological deterioration in patients with acute mild non-disabling ischemic stroke
目的 探讨急性轻型非致残性缺血性脑卒中患者的血压变异性(BPV)与早期神经功能恶化(END)及预后的相关性.方法 回顾性连续纳入2022年1月—2024年8月内蒙古民族大学附属医院卒中中心收治的急性轻型非致残性缺血性脑卒中患者,依据患者是否发生END分为无END组和END组.通过收集患者的一般资料、临床资料和结局指标后进行二元Logistic回归分析确定患者发生END的独立危险因素.根据改良Rankin量表(mRS)评分,将患者分为预后良好组(mRS评分≤2分)和预后不良组(mRS评分>2分),通过单因素Logistic回归分析评估END对患者90 d神经功能预后的影响.结果 最终纳入61例患者,其中END组14例,无END组47例.在收缩压变异系数上,END组与无END组差异有统计学意义(P<0.05).二元Logistic回归分析表明,收缩压血压变异系数四分位数>75%(BPV>75%)是发生END的独立危险因素(OR=14.000,95%CI 1.471～133.233,P=0.011);与无END组相比,END组患者90 d预后不良比例更高.90 d预后共有11例预后不良患者、50例预后良好患者.单因素Logistic回归结果表明,导致不良预后的独立危险因素为END(OR=19.556,95%CI 4.038～94.696,P<0.001).结论 在急性轻型非致残性缺血性脑卒中患者中,收缩压变异系数升高是导致END的独立危险因素,同时影响90 d神经功能预后.
Objective To investigate the association of blood pressure variability(BPV)with early neurological de-terioration(END)and prognosis in patients with acute mild non-disabling ischemic stroke.Methods The patients with acute mild non-disabling ischemic stroke who were admitted to Stroke Center of Affiliated Hospital of Inner Mongolia Uni-versity for Nationalities from January 2022 to August 2024 were enrolled,and according to the presence or absence of END,they were divided into non-END group and END group.General information,clinical data,and outcome measures were collected from all patients,and a binary logistic regression analysis was performed to determine independent risk fac-tors for END.According to the modified Rankin Scale(mRS)score,the patients were divided into good prognosis group(mRS score≤2 points)and poor prognosis group(mRS score>2 points),and a univariate logistic regression analysis was performed to investigate the influence of END on the 90-day neurological function prognosis of patients.Results A total of 61 patients were enrolled,with 14 patients in the END group and 47 patients in the non-END group.There was a signifi-cant difference in the coefficient of systolic pressure variation between the END group and the non-END group(P<0.05).The binary logistic regression analysis showed that systolic BPV(BPV>75%)was an independent risk factor for END(OR=14.000,95%CI 1.471-133.233,P=0.011).Compared with the non-END group,the END group had a significantly higher proportion of patients with a poor 90-day prognosis.Of all patients,there were 11 patients with poor prognosis and 50 patients with good prognosis on day 90.The uni-variate logistic regression analysis showed that END(OR=19.556,95%CI 4.038-94.696,P<0.001)was an independent risk factor for poor prognosis.Conclusion In patients with acute mild non-disabling ischemic stroke,the increase in coefficient of systolic pressure variation is an independent risk factor for END and affects the prognosis of neurological function on day 90.
马咏馨;杨璐;丛殿宝;张萌;秦贺;贾鸿博;李薇;张东威;徐耀铭
内蒙古医科大学通辽临床医学院,内蒙古 通辽 028000乌兰察布中医蒙医医院神经内科,内蒙古 乌兰察布 012000通辽市科尔沁区第一人民医院神经内科,内蒙古 通辽 028000内蒙古民族大学附属医院神经病学中心,内蒙古 通辽 028000内蒙古民族大学附属医院神经病学中心,内蒙古 通辽 028000内蒙古民族大学附属医院神经病学中心,内蒙古 通辽 028000内蒙古民族大学附属医院神经病学中心,内蒙古 通辽 028000内蒙古民族大学附属医院神经病学中心,内蒙古 通辽 028000内蒙古医科大学通辽临床医学院,内蒙古 通辽 028000||内蒙古民族大学附属医院神经病学中心,内蒙古 通辽 028000
医药卫生
急性轻型缺血性脑卒中非致残早期神经功能恶化血压变异预后
Acute mild ischemic strokeNon-disablingEarly neurological deteriorationBlood pressure variabilityPrognosis
《中风与神经疾病杂志》 2026 (3)
232-237,6
内蒙古自治区慢性病中(蒙)西医结合基础研究与转化创新中心开放课题(MDK2023001)内蒙古自治区重点研发和成果转化计划(2025YFSH0081)
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