急性脑梗死患者血清BHLHE40、SERPINE1、BLVRB水平与其颈动脉粥样硬化程度、近期预后的关系OA

Objective To investigate the serum levels of basic helix-loop-helix transcription factor 40(BHLHE40),serine protease inhibitor family E member 1(SERPINE1),and biliverdin reductase B(BLVRB)in pa-tients with acute cerebral infarction(ACI)and their association with the degree of carotid atherosclerosis(CAS)and short-term prognosis.Methods A total of 112 ACI patients who were admitted to our hospital from April 2023 to August 2024 were enrolled as study group,and 110 healthy individuals who underwent physical examination in our hospital were enrolled as control group.According to intima-media thickness(IMT),the patients in the study group were further di-vided into normal group with 22 patients,thickening group with 38 patients,and plaque group with 52 patients;based on the results of prognostic evaluation,the patients in the study group were divided into good prognosis group with 68 patients and poor prognosis group with 44 patients.ELISA was used to measure the expression levels of BHLHE40,SERPINE1,and BLVRB in the serum of ACI patients.Multivariate logistic regression analysis of risk factors for poor prognosis in ACI;ROC curve analysis of the predictive value of BHLHE40,SERPINE1,and BLVRB.Results Compared with the control group,the study group had significant increases in the serum levels of BHLHE40,SERPINE1,and BLVRB(P<0.05).Compared with the normal group,the thickening group and the plaque group had significant increases in the serum levels of BHLHE40,SERPINE1,and BLVRB,and the plaque group had significantly higher levels than the thickening group(P<0.05).Compared with the good prognosis group,the poor prognosis group had significant increases in the serum lev-els of BHLHE40,SERPINE1,and BLVRB and a significant increase in NIHSS score(P<0.05).The area under the curve(AUC)for the combined prediction of poor prognosis in ACI using BHLHE40,SERPINE1,and BLVRB was 0.939;the AUC for the combined prediction was superior to that of individual predictions(Z=3.804,3.197,3.240,P<0.05).Conclusion Elevated serum levels of BHLHE40,SERPINE1,and BLVRB in ACI patients are associated with disease severity and prognosis;the combined use of these three markers has some value in predicting poor outcomes in ACI patients.