远端肢体缺血后适应治疗对急性缺血性脑卒中患者血清MMP-9、HIF-1α、IL-1β水平的影响OA

Objective To investigate the effect of remote ischemic postconditioning(RIPostC)on the serum levels of matrix metallopeptidase-9(MMP-9),hypoxia-inducible factor 1α(HIF-1α),and interleukin-1β(IL-1β)in patients with acute ischemic stroke(AIS),and to further clarify the mechanism and clinical significance of RIPostC in the treat-ment of AIS.Methods A total of 115 AIS patients who were admitted to Suzhou First People's Hospital from May 2024 to February 2025 were enrolled,among whom 60 patients receiving conventional treatment were enrolled as control group,and 55 patients receiving RIPostC combined with conventional treatment for 7 consecutive days were enrolled as experi-mental group.ELISA was used to measure the serum levels of MMP-9,HIF-1α,and IL-1β,and National Institutes of Health Stroke Scale(NIHSS)was used to assess neurological function.Results After treatment,the experimental group had a significant increase in the level of HIF-1α(P<0.001)and significant reductions in the levels of MMP-9 and IL-1β(P<0.001).The experimental group had a significantly better NIHSS score than the control group(P<0.001).The in-crease in the serum level of HIF-1α could promote neurological function recovery.Conclusion RIPostC combined with conventional treatment can promote early neurological recovery in AIS patients,possibly by regulating the HIF-1α signal-ing pathway.