氮掺杂石墨烯量子点与血卟啉仿生的氨基锌酞菁偶联物光动力抗菌研究OA

Bacterial resistance has emerged as a critical global health challenge,underscoring the urgent need for the development of novel therapeutic strategies.In this study,we report the synthesis of a novel nanoconjugate(NGQDs-ZnTAPc),in which Hemoporphyrin-Inspired Zinc Tetraaminophthalocyanine(ZnTAPc)is covalently linked to nitrogen-doped graphene quantum dots(NGQDs)to enhance the efficacy of photodynamic therapy(PDT).This enhancement is primarily attributed to efficient Förster resonance energy transfer(FRET),with an energy transfer efficiency of 57.32％.Antibacterial experiments demonstrated that under red-light irradiation at 730 nm(200 mW/cm2,20 min),the survival rate of Staphylococcus aureus(S.aureus)decreased to 4.6％,which was markedly superior to that achieved with NGQDs or ZnTAPc alone.These results indicate that the NGQDs-ZnTAPc nanoconjugate holds considerable promise for applications in antibacterial photodynamic therapy.