普鲁士蓝@植酸-THPP纳米颗粒的光热和光动力抗菌效果OA
Photothermal and Photodynamic Antibacterial Effects of Phytic Acid@Prussian Blue-THPP Nanoparticles
针对细菌感染及耐药菌带来的公共卫生挑战,本研究致力于以普鲁士蓝(PB NPs)和四(间羟基苯基)卟啉(THPP)为核心,利用植酸(PA)为桥梁合成了PB@PA-THPP NPs(PPTP)复合物.表征分析显示,该材料具备优异的近红外双光响应能力:在808 nm激光下温度可急剧上升50℃以上,展现显著光热效应;在650 nm激发下能有效产生活性氧,展现显著光动力性能.体外实验证实,该材料生物相容性良好.在0.5 mg/mL浓度下,对金黄色葡萄球菌的灭菌率超过99%.该研究成功构建了双模式纳米平台,为临床抗感染治疗提供了新思路.
Addressing the public health challenges posed by bacterial infections and a wide range of microorganisms,this study synthesized a PB@PA-THPP NPs(PPTP)complex using Prussian blue(PB NPs)and tetra(m-hydroxyphenyl)porphyrin(THPP)as the core components and phytic acid(PA)as a bridge.Characterization analysis revealed that this material exhibits excellent near-infrared dual-light response:its temperature can rise sharply by more than 50℃under 808 nm laser light,demonstrating a significant photothermal effect;and it can effectively generate reactive oxygen species(ROS)under 650 nm excitation.In vitro experiments confirmed that the material has good biocompatibility.At a concentration of 0.5 mg/mL,it achieved a sterilization rate of over 99%against Staphylococcus aureus.This study successfully constructed a dual-mode nanoplatform,providing a new approach for clinical anti-infective therapy.
何明阳;靳焘
中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049||中国科学院新型特种精细化学品工程实验室,广东 广州 510650||国科广化韶关新材料研究院,广东 韶关 512400||国科广化精细化工孵化器(南雄)有限公司,广东 南雄 512400
医药卫生
卟啉光动力疗法光热疗法普鲁士蓝植酸协同抗菌
porphyrinphotodynamic therapyphotothermalprussian bluephytic acidantibacterial
《纤维素科学与技术》 2026 (1)
16-22,7
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