牙龈卟啉单胞菌在消化系统肿瘤发生发展中的角色和相关机制OA

The pathogenic role of Porphyromonas gingivalis(P.gingivalis),a key pathogen in periodontitis,has been well documented to extend far beyond the oral cavity.P.gingivalis can be specifically detected in digestive system tumor tissues,and its infection abundance is closely associated with tumor invasion,metastasis,and poor prognosis in patients.This study systematically reviews basic and clinical research on the association between P.gingivalis and digestive system tumors including oral cancer,esophageal cancer,pancreatic cancer,liver cancer,and colorectal cancer.The potential molecular mechanisms underlying P.gingivalis-induced tumor initiation and progression were further elucidated thoroughly,aiming to provide new theoretical basis and research directions for risk warning,early diagnosis,and targeted therapy of digestive system tumors.