前列腺癌的生物力学视角:病理机制、诊断革新与靶向干预OA

Prostate cancer(PCa)is one of the most prevalent malignancies in men worldwide.Its progression is not only driven by molecular and genetic alterations but also significantly influenced by mechanical cues in the tumor microenvironment.Biomechanics,an interdisciplinary field exploring the role of physical forces in biological systems,has emerged as a novel lens for cancer research.This review summarizes recent advances in the biomechanical study of PCa,including tissue stiffness heterogeneity,cellular mechanical phenotypes,extracellular matrix remodeling,and fluid shear stress in tumor progression.We further highlight the clinical implications of biomechanics in early detection,benign-malignant lesion discrimination,and multi-modal diagnostic imaging.Moreover,the therapeutic potential of biomechanical approaches was discussed,including modulation of therapeutic sensitivity,targeting mechano-signaling pathways,developing mechanically responsive nanocarriers,and applying external mechanical interventions.Despite current challenges such as a lack of standardization and limited clinical translation,interdisciplinary collaboration holds promise for advancing biomechanically informed precision medicine in PCa.