正交试验结合AHP-CRITIC法优化芍药甘草汤水煎液提取工艺OA

To optimize the extracting process of Shaoyao Gancao decoction,a multi-index comprehensive weighted scoring method combined with an orthogonal test was applied.An HPLC method was established for the simultaneous determination of 4 ingredients including paeoniflorin,albiflorin,liquiritin and glycyrrhizic acid.The L9(34)orthogonal table was adopted to investigate the effects of soaking time,water amount,decocting time and extracting times on the water-extracting process of Shaoyao Gancao decoction.Yield ratios and the contents of index components were used as evaluation indexes,and the weight coefficient of each index was determined by using AHP,CRITIC,or AHP-CRITIC method.The extracting process parameters of Shaoyao Gancao decoction were then determined by analyses in the orthogonal test.The optimized extraction process of Shaoyao Gancao decoction was confirmed to involve adding an eightfold amount of water(w/v),soaking for 20 minutes,and then extracting three times for 60 minutes each time..The orthogonal test method combined with AHP-CRITIC mixed weighting method provided a reliable and stable scheme for the optimized extracting of Shaoyao Gancao decoction.