USP19:解锁肿瘤细胞功能网络"密码"的关键分子OA
USP19:key molecule unlocking the"code"of the tumor cell functional network
泛素特异性蛋白酶19(USP19)作为去泛素化酶家族的关键成员,深度参与了细胞内多种生物学进程的调控.近年来,大量研究表明,USP19在肿瘤的发生、发展、转移及耐药等环节中扮演着至关重要的角色.该文不仅全面深入地综述了USP19的结构、功能、在肿瘤中的作用机制及最新研究进展,更创新性地从全新理论框架整合现有研究,提出潜在研究方向,旨在为肿瘤的诊治及预后评估开辟全新的思路,提供极具潜力的靶点.
Ubiquitin-specific protease 19(USP19),as a key member of the deubiquitinating enzyme family,is deeply involved in the regulation of various biological processes within cells.In recent years,a large number of studies have shown that USP19 plays a crucial role in the processes of tumor occurrence,develop-ment,metastasis,and drug resistance.This article not only comprehensively and thoroughly reviews the struc-ture,function,mechanism of action in tumors,and the latest research progress of USP19,but also innovatively integrates existing research from a new theoretical framework and proposes potential research directions.The aim is to open up new ideas for the diagnosis,treatment,and prognosis evaluation of tumors and provide highly potential targets.
张春秋;许超
上海市第十人民医院崇明分院检验科,上海 202157上海市第十人民医院崇明分院检验科,上海 202157
医药卫生
泛素特异性蛋白酶19肿瘤细胞功能网络作用机制治疗靶点综述
Ubiquitin-specific protease 19Tumor cell functional networkMechanism of actionTherapeutic targetReview
《现代医药卫生》 2026 (3)
522-526,5
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