C反应蛋白/白蛋白比值在自发性脑出血患者早期病情判断及预后评估中的价值OA

Objective To explore the value of C-reactive protein(CRP)/albumin(Alb)in assessing the severity and predic-ting the prognosis of patients with spontaneous intracerebral hemorrhage(ICH).Methods A total of 98 patients with ICH admitted to the 980th Hospital of PLA Joint Logistics Support Force from January 2023 to January 2024 were selected as the observation group,and they were divided into a severe group(≥15 points,n=37)and a moderate-to-mild group(<15 points,n=61)according to the sever-ity of the disease.According to the prognosis outcome,they were further divided into a good prognosis group(<3 points,n=69)and a poor prognosis group(≥3 points,n=29).Another 100 healthy individuals who were tested during the same period were selected as the control group.The data of the research subjects were collected,and the quantitative results of CRP and Alb on the 1st,7th,and 14th day after admission were detected.The CRP/Alb ratio was calculated.The CRP,Alb and CRP/Alb ratio of the observation group on the 1st day of admission were compared with those of the control group.The CRP,Alb,and CRP/Alb ratios of ICH patients with different conditions on the 1st,7th,and 14th day of admission,and the clinical features of ICH patients with different prognoses were compared.Logistic regression model was used to to analyze the influencing factors of poor prognosis in ICH patients.The receiver oper-ating characteristic(ROC)curve was used to predict the prognostic efficacy of CRP/Alb ratio in ICH patients.Results The CRP and CRP/Alb ratios in the observation group were higher than those in the control group,while Alb was lower than that in the control group(P<0.05).The CRP and CRP/Alb ratios of two groups of ICH patients with different disease severity significantly increased on the 7th and 14th day of admission compared to the 1st day,and the CRP and CRP/Alb ratios of the severe group were higher than those of the moderate-to-mild group on the 1st day,7th and 14th day of admission,while the Alb on the 14th day of admission was lower than that of the moderate-to-mild group(P<0.05).There were differences in age,diabetes,NIHSS,cerebral hemorrhage,CRP,CRP/Alb ra-tio on the 1st,7th,and 14th day after admission,and Alb on the 7th and 14th days after admission among ICH patients with different prognosis(P<0.05).The results of Logistic regression analysis showed that age,NIHSS,volume of intracerebral hemorrhage,CRP on the 7th day,and the CRP/Alb ratio were independent influencing factors for poor prognosis of ICH patients,while Alb on the 7th day was a protective factor(P<0.05).The ROC curve results showed that the area under the curve(AUC)of predicting poor prognosis in ICH patients by the CRP/Alb ratio on the 7th day of admission was 0.845(0.752-0.938),which was higher than that of CRP and Alb alone(P<0.05).Conclusions The CRP/Alb ratio can be used for the differentiation,evaluation,and prognosis of ICH disease.Compared with a single indicator,the combined quantitative evaluation has a higher predictive effect on prognosis outcomes of ICH pa-tients.