针刺干预慢性疼痛伴抑郁的分子机制研究进展OA

Chronic pain is often accompanied by depressive emotions,and they are interacted with each other,which is one of the crucial factors to affect the clinical efficacy on pain.Acupuncture therapy has the advantages of multi-dimensional and multi-target regulation,and it is remarkably effective on chronic pain and pain-related depressive emotions.This paper reviews the mechanism researches of acupuncture in treatment of chronic pain with depression.Research indicates that the primary molecular mechanism by which acupuncture exerts analgesic and anti-depressive effects involves the regulation of central ner-vous system neurotransmitters,including 5-hydroxytryptamine,glutamic acid,gamma-aminobutyric acid,and dopamine.Additionally,acupuncture inhibits inflammatory responses within the central nervous sys-tem,modulates the expression of neurotrophic factors,enhances neuronal synaptic plasticity,and regu-lates the BDNF/TrkB/CREB and ERK signaling pathways.These findings underscore the multifaceted and multi-targeted regulatory advantages of acupuncture.