梭菌属(Clostridium)产乙酸菌代谢工程改造与合成气定向转化研究现状OA

The development of microbial carbon sequestration technology is crucial for curbing global warming.Acetogenic Clostridium can fix one-carbon gases,such as CO2 and CO,and convert them into chemical products,such as ethanol,thereby reducing dependence on fossil fuels,which makes acetogenic Clostridium a promising strain for converting syngas into high-value products on a large scale.This review summarizes the research progress in metabolic engineering modifications of acetogenic Clostridium and the directional conversion of syngas.Firstly,the energy metabolism modes of acetogenic Clostridium are analyzed,and the energy conservation mechanisms of acetogenic Clostridium are elaborated.Then,various tools for genetic manipulation of acetogenic Clostridium are compared and summarized.Finally,the current prospects and challenges in the two major directions of metabolic engineering modification of acetogenic Clostridium are sorted out.In conclusion,this paper summarizes the research progress in metabolic engineering of acetogenic Clostridium in recent years,aiming to provide references for more comprehensive understanding of its syngas conversion potential,and promote the development of renewable energy production platform using industrial acetogenic Clostridium.