2023年12月—2024年11月浙江省安吉县流感样病例病原学特征分析OA

[Objective]To analyze the infection status of main respiratory pathogens in influenza-like illness(ILI)cases in Anji County,Huzhou City,Zhejiang Province,and to provide a reference for the prevention,diagnosis,and treatment of respiratory infections.[Methods]Throat swab samples were collected from 520 ILI cases in an influenza sentinel surveillance hospital in Anji County of Zhejiang Province from December 2023 to November 2024.Multiplex real-time fluorescence quantitative polymerase chain reaction(mRT-PCR)was used to detect 18 pathogens and their subtypes,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),influenza A virus(Flu A),influenza A(H1N1)virus,influenza A(H3N2)virus,influenza B virus(Flu B),influenza B virus Victoria lineage(BV),influenza B virus Yamagata lineage(BY),coronavirus(CoV),human parainfluenza virus(HPIV),respiratory syncytial virus(RSV),human metapneumovirus(HMPV),adenovirus(ADV),human bocavirus(HBoV),enterovirus(EV),rhinovirus(RV),Mycoplasma pneumoniae(MP),Chlamydia pneumoniae(CP),and Streptococcus pneumoniae(SP).[Results]The overall positivity rate of pathogens in 520 samples was 33.65%,among which the detection rates of Flu(9.14%),ADV(7.50%),SARS-CoV-2(6.15%),and EV(3.65%)were relatively high.There were statistically significant differences in the overall positivity rate of pathogens by age and season(all P<0.05).The highest overall positivity rate was observed in the 5‒14 years old group(42.77%),and the overall positivity rate in winter(53.08%)was significantly higher than that in other seasons.[Conclusion]From 2023 to 2024,the main respiratory pathogens detected in ILI cases in Anji County were Flu,ADV,SARS-CoV-2,and EV.The epidemic characteristics showed age and seasonal specificity,so it is necessary to strengthen prevention and control for high-risk populations and epidemic seasons in a targeted manner.