SII、NLR、PLR、LMR对食管癌放疗患者近期预后的预测价值OA

Aim To analyze the predictive value of systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and lymphocyte-to-monocyte ratio(LMR)for the short-term prognosis of esophageal cancer patients undergoing radiotherapy.Methods A total of 82 esophageal cancer patients who received radiotherapy were enrolled as the observation group.Based on the 12-month follow-up outcomes,they were divided into a poor prognosis group(33 cases)and a good prognosis group(49 cases).Another 41 healthy individuals undergoing physical examination during the same period were selected as the control group.Peripheral blood SII,NLR,PLR,and LMR values were compared between the observation group and the control group,as well as between the poor and good prognosis groups.The ROC curve was used to analyze the predic-tive value of individual and combined indicators for short-term prognosis.Results The peripheral blood SII,NLR,and PLR val-ues in the observation group were higher than those in the control group,while the LMR value was lower(P<0.05).In the poor prognosis group,SII,NLR,and PLR values were higher than those in the good prognosis group,whereas the LMR value was lower(P<0.05).ROC curve analysis showed that the AUC for the combined prediction of short-term prognosis by SII,NLR,PLR,and LMR was higher than that of each indicator alone,with a sensitivity of 78.79%and a specificity of 85.71%,respectively.Con-clusion Peripheral blood SII,NLR,PLR,and LMR values are abnormally expressed in esophageal cancer patients undergoing radio-therapy.The combined detection of these indicators can improve the predictive efficacy for short-term prognosis.