获得性免疫缺陷综合征相关卡波西肉瘤多器官受累特征与诊疗策略OA

Kaposi sarcoma(KS)is a multicentric tumor closely associated with immunosuppression and KS-associated herpesvirus(KSHV)infection.The synergistic interaction between KSHV infection and human immunodeficiency virus(HIV)infection promotes the occurrence and progression of acquired immunodeficiency syndrome(AIDS)-associated KS(AIDS-KS).AIDS-KS is one of the most common malignancies in AIDS patients and thus requires high clinical attention.This article systematically reviews the multicentric pathogenesis of AIDS-KS,the specific clinical manifestations of involvement in different organs and stratified diagnostic and therapeutic strategies,with particular emphasis on the importance of combining antiretroviral therapy(ART)and targeted therapy in disease management.The implementation of individualized and multidisciplinary comprehensive management strategies can better control disease progression and improve patients'quality of life as well as prognosis.