慢加急性肝衰竭前期的研究现状OA
Current status of research on pre-acute-on-chronic liver failure
慢加急性肝衰竭(ACLF)是一种在慢性肝病基础上由急性诱因引发的高病死率综合征,临床发现ACLF具有一定可逆性,早期干预可改善预后,延误诊治则显著增加病死率.近年来,领域内学者提出"ACLF前期"(Pre-ACLF)概念,旨在通过早期识别和干预改善临床结局.本文系统回顾了Pre-ACLF的概念起源及国内外的最新定义,总结了Pre-ACLF研究中传统临床-实验室指标、高通量组学和分子生物学机制的最新进展;并提出需进一步统一Pre-ACLF定义的重要临床需求.
Acute-on-chronic liver failure(ACLF)is a syndrome with high mortality triggered by acute predisposing factors in patients with underlying chronic liver diseases.Clinical studies have shown that ACLF can be reversed to a certain degree,and early intervention can improve patient prognosis,whereas delayed diagnosis and treatment can lead to a significant increase in mortality.In recent years,scholars in this field have proposed the concept of"pre-acute-on-chronic liver failure(Pre-ACLF)",which aims to improve clinical outcomes through early identification and intervention.This article systematically reviews the origin of the Pre-ACLF concept and its latest definitions in China and globally,summarizes the latest research advances in Pre-ACLF in terms of traditional clinical-laboratory parameters,high-throughput omics,and molecular biological mechanisms,and proposes the important clinical need for further unifying the definition of Pre-ACLF.
赵睿;焦婧然;陈煜
首都医科大学附属北京佑安医院肝病中心四科,北京 100069首都医科大学附属北京佑安医院肝病中心四科,北京 100069首都医科大学附属北京佑安医院肝病中心四科,北京 100069
慢加急性肝功能衰竭终末期肝病早期诊断
Acute-On-Chronic Liver FailureEnd Stage Liver DiseaseEarly Diagnosis
《临床肝胆病杂志》 2026 (2)
286-292,7
首都卫生发展科研专项项目(首发2024-1-2181)高层次公共卫生技术人才建设项目资助(学科带头人-01-12)北京市医院管理中心"登峰"计划专项经费资助(DFL20221501)国家重点研发计划项目(2022YFC2304402) Capital's Funds for Health Improvement and Research(CFH2024-1-2181)Construction Project of High-level Technology Talents in Public Health(Discipline leader-01-12)Beijing Hospitals Authority's Ascent Plan(DFL20221501)National Key Research and Development Program of China(2022YFC2304402)
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