伴FGFR2基因易位的肝内胆管癌临床病理特征OA

Objective To investigate the clinicopathological characteristics and molecular features of intrahe-patic cholangiocarcinoma(ICC)with fibroblast growth factor receptor 2(FGFR2)gene translocation.Methods The clinical manifestations,imaging findings,pathological features,and molecular characteristics of eight cases of ICC with FGFR2 translocation were retrospectively analyzed and compared with those of 32 cases of FGFR2 translocation-negative ICC.Results Tumor cells in ICC with FGFR2 translocation were cuboidal or polygonal and exhibited anasto-mosing tubular,trabecular,solid nested,or papillary growth patterns within a fibrosclerotic stroma.Compared with FGFR2 translocation-negative ICC,FGFR2 translocation-positive ICC showed a higher rate of hepatitis B virus infec-tion(P=0.042)and more frequently demonstrated small bile duct type or mixed histological subtypes(P=0.037).The mutation or expression rates of p53,HER2,c-Met,and BRAF V600E tended to be lower in FGFR2 translocation-positive ICC,although the differences were not statistically significant(P>0.05).The area under the receiver operat-ing characteristic curve(AUC)for predicting FGFR2 translocation by combining sex,hepatitis B virus infection sta-tus,TNM stage,histological subtype,and tumor nuclear grade was 0.912(P<0.001),which was higher than that of any single feature alone.Compared with FGFR2-translocated ICC harboring wild-type TP53,FGFR2-translocated ICC with TP53 co-mutation exhibited a higher nuclear grade(P=0.036),more advanced TNM stage(P=0.036),and poorer overall survival(P=0.009).Conclusion Distinct clinicopathological features are helpful for screening ICC with FGFR2 gene fusions and for identifying cases with TP53 co-mutation,thereby facilitating more precise treat-ment strategies for patients with ICC.