血浆致动脉硬化指数联合同型半胱氨酸对2型糖尿病合并非酒精性脂肪性肝病的风险预测OA

Objective To investigate the predictive value of plasma atherogenic index of plasma(AIP)combined with homocysteine(Hcy)for type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD).Methods A total of 325 patients with T2DM who were admitted from January 2023 to January 2025 were selected.They were divided into the T2DM group(n=129)and the T2DM combined with NAFLD group(n=196)based on whether they had NAFLD.The clinical data and laboratory indicators of the two groups were compared.Pearson correlation analysis was used to analyze the relationship between AIP and related indicators.Multivariate logistic regression analysis was employed to analyze the influencing factors of NAFLD in T2DM patients.The receiver operating characteristic(ROC)curve was used to investigate the predictive value of AIP combined with Hcy for T2DM combined with NAFLD.Results Compared with the T2DM group,the T2DM combined with NAFLD group showed elevated levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamyl transferase(GGT),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),AIP,and Hcy,and decreased levels of high-density lipoprotein cholesterol(HDL-C)(P<0.05).AIP was positively correlated with AST,ALT,GGT,TG,LDL-C,and Hcy,and negatively correlated with HDL-C(P<0.05).Elevated AIP,AST,ALT,GGT,TG,LDL-C,and Hcy were independent risk factors for the occurrence of NAFLD in T2DM,while elevated HDL-C was a protective factor(P<0.05).The combination of AIP and Hcy had the optimal predictive efficacy,with an area under the curve of 0.641,a sensitivity of 52.71%,and a specificity of 78.75%.Conclusion The combination of AIP and Hcy has certain predictive value for T2DM patients with NAFLD.