中国内脏脂肪指数与消化系统恶性肿瘤发病风险的相关性分析OA
Correlation analysis between Chinese visceral adiposity index and the risk of digestive system malignant tumors
目的 依托开滦队列,探究中国内脏脂肪指数(CVAI)与消化系统恶性肿瘤发病风险的关系.方法 采用前瞻性队列研究的方法,共101 510名员工参与2006年度开滦健康体检,排除基线癌症病史者、CVAI数据和相关协变量缺失者,最终纳入94 926名.按参与者CVAI四分位数分为4组:Q1组(CVAI<63.62,n=23 732)、Q2组(63.62≤CVAI<91.83,n=23 733)、Q3组(91.83≤CVAI<118.31,n=23 731)、Q4组(CVAI≥118.31,n=23 730).采用多因素Cox比例风险回归模型分析不同CVAI值对消化系统恶性肿瘤发病风险的影响.根据参与者的年龄、性别、体重指数(BMI)、吸烟情况、饮酒情况进行亚组分析,并分别在排除随访1年内患消化系统恶性肿瘤和服用降脂药的参与者后进行敏感性分析.结果 在94 926名参与者中,男性75 748名(79.8%),女性19 178名(20.2%),随访时间为(14.1±2.7)年,至研究结束时,新发消化系统恶性肿瘤2029例.Q1-Q4组消化系统恶性肿瘤发病密度分别为1.11/千人年、1.38/千人年、1.67/千人年、1.90/千人年.在校正相关协变量后,与Q1组相比,Q2组(HR=1.15,95%CI 1.02～1.31)、Q3组(HR=1.35,95%CI 1.18～1.54)、Q4组(HR=1.52,95%CI 1.33～1.73)的消化系统恶性肿瘤发病风险明显增加.结论 高CVAI值与消化系统恶性肿瘤发病风险呈正相关.
Objective To investigate the relationship between the Chinese visceral adiposity index(CVAI)and the risk of digestive system malignant tumors based on the Kailuan cohort.Methods A prospective cohort study was conducted,and a total of 101,510 participants who underwent the Kailuan health examination in 2006 were included.After excluding individuals with a history of baseline cancer,missing CVAI data and related covariates,94 926 participants were finally included.Participants were categorized into 4 groups based on CVAI quartiles:Q1 group(CVAI<63.62,n=23 732),Q2 group(63.62≤CVAI<91.83,n=23 733),Q3 group(91.83≤CVAI<118.31,n=23 731),and Q4 group(CVAI≥118.31,n=23 730).A multivariate Cox proportional hazards regression model was used to analyze the impact of different CVAI values on the risk of digestive system malignant tumors.Subgroup analyses were performed according to participants'age,gender,body mass index(BMI),smoking status,and alcohol consumption status.Sensitivity analyses were conducted by excluding participants who developed digestive system malignant tumors within 1 year of follow-up and those taking lipid-lowering medications,respectively.Results Among the 94 926 participants,75 748 were male(79.8%)and 19 178 were female(20.2%).The median follow-up duration was(14.1±2.7)years.By the end of the study,2029 new cases of digestive system malignant tumors were identified.The incidence densities of digestive system malignant tumors in Q1-Q4 groups were 1.11,1.38,1.67,and 1.90 per 1000 person-years,respectively.After adjusting for relevant covariates,compared with Q1 group,the risk of digestive system malignant tumors in Q2 group(HR=1.15,95%CI 1.02-1.31),Q3 group(HR=1.35,95%CI 1.18-1.54),and Q4 group(HR=1.52,95%CI 1.33-1.73)was significantly increased.Conclusion A high CVAI value is positively correlated with the risk of digestive system malignant tumors.
李佳兴;马超;刘款;王万超;田园;吴寿岭;陈朔华;董智刚;刘四清
华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000华北理工大学附属开滦总医院健康保障中心,河北 唐山 063000华北理工大学附属开滦总医院健康保障中心,河北 唐山 063000华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000
医药卫生
中国内脏脂肪指数消化系统恶性肿瘤肥胖内脏脂肪
Chinese visceral adiposity indexdigestive system malignant tumorobesityvisceral fat
《解放军医学杂志》 2026 (2)
211-218,8
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