中医药调控炎症因子治疗放射性肠炎研究进展OA

Radiation enteritis(RE)is a severe intestinal complication resulting from radiotherapy in patients with pelvic,abdominal,or retroperitoneal malignancies.The imbalance between pro-inflammatory and anti-inflammatory factors,along with the cascade of inflam-matory mediators,constitutes the core pathological link in the onset of RE.This paper has systematically reviewed recent research pro-gress on the intervention of RE by TCM through the regulation of inflammatory factors.It has revealed that TCM monomers and com-pound formulas can mitigate intestinal inflammation,repair barrier function,and inhibit cell apoptosis through multiple effects,such as regulating the inflammatory factor network and related signaling pathways(e.g.,NF-κB,NLRP3,MAPK).This demonstrates the u-nique advantages of multi-target action and holistic regulation,indicating promising potential for clinical application.However,this field still faces the following challenges:(1)The analysis of pharmacodynamic mechanisms is not sufficiently precise,with inadequate in-depth research on the direct targets of drug action(e.g.,receptors,kinases),the specific processes of signal transduction,and the syn-ergistic mechanisms underlying the"sovereign-minister-assistant-courier"principle within compound formulas;(2)Research predomi-nantly focuses on single pathways,failing to systematically elucidate the holistic regulatory role of TCM in the synergy or antagonism a-mong multiple pathways;(3)Research is primarily centered on the verification of traditional formulas,with limited research on new compound formulas,new compatibilities,and innovative intestinal-specific dosage forms.Therefore,future research could employ tech-nologies such as molecular docking,gene editing,and proteomics,etc.to precisely identify direct action targets and elucidate the syner-gistic mechanisms of compound formula components.Furthermore,integrating multi-omics approaches with network pharmacology meth-ods to construct systematic regulatory networks is crucial,with a focus on exploring the synergistic patterns of TCM in regulating multiple inflammatory pathways.Leveraging novel models like organoids and organs-on-chips,etc.will be key to strengthening the innovative de-velopment and translational research of new Chinese medicinals,novel dosage forms,and new drug delivery systems.