8种水产药物对膨腹海马幼苗急性毒性试验及安全评价OA

[Objective]The study aims to determine the safe concentrations of eight commonly used aquacul-ture drugs(trichloroisocyanuric acid,formaldehyde,copper sulfate,hydrogen peroxide,zinc sulfate,metalaxyl,benzalkonium bromide,and niclosamide)for Hippocampus abdominalis,providing theoretical guidance for breeding,medication practices,and disease prevention in H.abdominalis aquaculture.[Methods]Under water temperatures of 16−18℃,juvenile H.abdominalis[average body length:4−6 cm;average body mass:(1.83±0.26)g]were exposed to these drugs using a semi-static water renewal and drug replenishment method.The acute toxicity and toxic accumulation characteristics were analyzed through the maximum accumulation coefficient(MAC).[Results]The MAC of 8 aquaculture drugs for juvenile H.abdominalis are all positive.Their safe concentrations(SC),ranked from highest to lowest are as follows:formaldehyde(24.858 mg/L),hydrogen peroxide(19.498 mg/L),trichloroisocyanuric acid(1.481 mg/L),metalaxyl(0.369 mg/L),copper sulfate(0.339 mg/L),benzalkonium bromide(0.247 mg/L),zinc sulfate(0.185 mg/L),and niclosamide(0.024 mg/L).[Conclusion]All eight drugs exhibited positive MAC values,indicating stronger cumulative tox-icity than detoxification effects.Toxicity classifications were:low toxicity for trichloroisocyanuric acid,formal-dehyde,and hydrogen peroxide;moderate toxicity for copper sulfate,zinc sulfate,and metalaxyl;and high tox-icity for niclosamide.