黄芪桂枝五物汤加味治疗糖尿病足溃疡疗效分析OA
Efficacy Analysis of Supplemented Astragalus and Cinnamon Twig Five-Substance Decoction in the Treatment of Diabetic Foot Ulcer
目的:观察黄芪桂枝五物汤加味治疗糖尿病足溃疡(diabetic foot ulcer,DFU)的临床疗效,并探讨其对患者血管内皮生长因子(vascular endothelial growth factor,VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)水平的影响.方法:将120 例DFU患者按随机数字表法分为对照组和观察组,每组各60 例.对照组给予常规治疗,观察组在对照组基础上予以黄芪桂枝五物汤加味治疗.比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、血管生长因子(VEGF、bFGF)、溃疡面积、代谢相关指标[空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)]、炎症因子[C反应蛋白(C reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)]变化情况.结果:观察组有效率为95.00%,高于对照组的83.33%,差异具有统计学意义(P<0.05).两组患者治疗后创口疼痛、溃破腐烂、皮肤暗紫、体热口干、便秘溲赤等中医证候积分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05).两组患者治疗后VEGF、bFGF水平高于本组治疗前,溃疡面积低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05).两组患者治疗后FPG、HbA1c、CRP、TNF-α、IL-6 水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:黄芪桂枝五物汤加味治疗DFU,可提高患者VEGF、bFGF水平,促进创面愈合,缓解症状,改善血糖状况,减轻炎症反应.
Objective:To observe the clinical efficacy of Supplemented Astragalus and Cinnamon Twig Five-Substance Decoction on dia-betic foot ulcer(DFU)and to investigate its effect on patients'levels of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF).Methods:A total of 120 DFU patients were divided into the control group and the observation group using the random number table method,with 60 cases in each group.The control group received conventional treatment,while the observation group received Supplemented Astragalus and Cinnamon Twig Five-Substance Decoction in addition to the control group's treatment.The clinical efficacy,incidence of adverse reactions,as well as changes in TCM syndrome scores,angiogenesis factors(VEGF,bFGF),ulcer area,blood glucose levels[fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c)],and inflammatory factors[including C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]before and after treatment were compared between the two groups.Results:The effective rate in the observation group was95.00%,which was higher than83.33%in the control group,and the difference was statistically significant(P<0.05).After treatment,TCM syndrome scores for wound pain,ulceration and putre-faction,dusky skin,bodily fever and dry mouth,constipation,and dark reddish urine were lower than those before treatment in the two groups,and the above scores in the observation group were lower than those in the control group(P<0.05).Levels of VEGFand bFGF were higher than those before treatment in the two groups,while ulcer area was lower than that before treatment,and all the differences were statistically significant(P<0.05).Levels of FPG,HbA1c,CRP,TNF-α,and IL-6 were lower than those before treatment in the two groups,and the levels in the observation group were lower than those in the control group(P<0.05).However,there was no statis-tically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Supplemented As-tragalus and Cinnamon Twig Five-Substance Decoction in the treatment of DFU patients can increase VEGF and bFGF levels,promote wound healing,alleviate symptoms,improve blood sugar status,and reduce inflammatory responses.
张东阳;张桂平;李明鹏
南阳市第二人民医院,河南 南阳 473000南阳市第二人民医院,河南 南阳 473000南阳市第二人民医院,河南 南阳 473000
医药卫生
糖尿病足溃疡黄芪桂枝五物汤加味血管内皮生长因子碱性成纤维细胞生长因子《金匮要略》张仲景
diabetic foot ulcer(DFU)Supplemented Astragalus and Cinnamon Twig Five-Substance Decoctionvascular endothelial growth factor(VEGF)basic fibroblast growth factor(bFGF)Synopsis of the Golden ChamberZhang Zhongjing
《河南中医》 2026 (4)
497-502,6
2024-2025年度南阳市科技计划项目(24KJGG246)
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