柴胡加龙骨牡蛎汤联合宁静贴干预经皮冠状动脉介入术后焦虑症的随机对照研究OA
A Randomized Controlled Study of Bupleurum Decoction Plus Dragon Bones and Oyster Shell Combined with Ningjing Patch in the Intervention of Anxiety After Percutaneous Coronary Intervention
目的:观察柴胡加龙骨牡蛎汤联合宁静贴干预经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后焦虑症的临床疗效及其对心身指标的调节作用.方法:选择2022 年1 月至2025 年1 月在湖北省中西医结合医院行PCI术后出现焦虑情绪的患者126 例,按照随机数字表法分为对照组和联合组,每组各63 例,对照组采用常规西医治疗,联合组在对照组治疗基础上采用柴胡加龙骨牡蛎汤联合宁静贴治疗,两组均治疗 8 周.观察两组患者治疗前后汉密尔顿焦虑量表(hamilton anxiety rating scale,HAMA)评分、焦虑自评量表(self-rating anxiety scale,SAS)评分、生活质量量表(the MOS 36-item short form health survey,SF-36)评分、左心室射血分数(left ventricular ejection fraction,LVEF)、中医证候积分及用药后的不良反应发生情况.结果:对照组有效率为79.37%,联合组有效率为 95.24%,两组有效率比较,差异具有统计学意义(P<0.05),治疗后,两组HAMA、SAS评分均较治疗前降低,且联合组低于对照组,差异具有统计学意义(P<0.05);LVEF较治疗前升高,中医证候积分较治疗前降低,且组间比较,差异具有统计学意义(P<0.05);生理功能评分、精神健康评分、总体健康评分、总分均较治疗前升高,且联合组高于对照组,差异具有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:柴胡加龙骨牡蛎汤联合宁静贴可显著改善PCI术后患者焦虑状态,提高其生活质量.
Objective:To observe the clinical efficacy of Bupleurum Decoction Plus Dragon Bones and Oyster Shell combined with Ningjing Patch in the intervention of anxiety following percutaneous coronary intervention(PCI)and its regulatory effect on psychoso-matic indicators.Methods:A total of 126 patients who developed anxiety after PCI at Hubei Provincial Hospital of Integrated Chinese&Western Medicine from January 2022 to January 2025 were selected and randomly divided into the control group and the combined group using the random number table method,with 63 cases in each group.The control group received conventional Western medicine treatment,while the combined group was treated with Bupleurum Decoction Plus Dragon Bones and Oyster Shell combined with Ningjing Patch in addition to the treatment given to the control group.Both groups were treated for 8 weeks.Then the following parameters were observed before and after treatment:Hamilton Anxiety Rating Scale(HAMA)score,Self-Rating Anxiety Scale(SAS)score,The MOS 36-Item Short Form Health Survey(SF-36)score,left ventricular ejection fraction(LVEF),Traditional Chinese Medicine(TCM)syn-drome scores,and the occurrence of adverse reactions after medication.Results:After treatment,the HAMA and SAS scores in the two groups all decreased compared with those before treatment,and the above scores in the combined group were lower than those in the control group,with statistically significant differences(P<0.05).LVEF increased compared with that before treatment,and TCM syn-drome scores decreased compared with those before treatment,with statistically significant differences between the two groups(P<0.05).The physical functioning score,mental health score,general health score,and total score increased compared with those before treatment,and the above scores in the combined group were higher than those in the control group,with statistically significant differ-ences(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Bupleurum Decoction Plus Dragon Bones and Oyster Shell combined with Ningjing Patch can significantly im-prove the anxiety state and enhance the quality of life in patients after PCI.
曹军;方婷婷;胡晓军;肖赢;刘亮
湖北省中西医结合医院,湖北 武汉 430021湖北省中西医结合医院,湖北 武汉 430021湖北省中西医结合医院,湖北 武汉 430021湖北省荣军医院,湖北 武汉 430021湖北省中医院,湖北 武汉 430021
医药卫生
PCI术后焦虑症柴胡加龙骨牡蛎汤宁静贴少阳不和、痰热内扰证《伤寒论》张仲景
after PCIanxietyBupleurum Decoction Plus Dragon Bones and Oyster ShellNingjing Patchsyndrome of lesser yang dis-harmony with internal harassment of phlegm-heatTreatise on Cold Damage DiseasesZhang Zhongjing
《河南中医》 2026 (4)
492-496,5
湖北省2021-2022年度中医药科研项目(面上项目)(ZY2021M070)
评论