NETs在ALI/ARDS病理生理中的作用OA
The role of NETs in ALI/ARDS pathophysiology
急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是一种高发病率、高死亡率的肺部炎性疾病,目前对于其诊治仍是全世界的重要难题.中性粒细胞的聚集和浸润对于该疾病的发生、发展起着关键作用,目前认为中性粒细胞通过释放中性粒细胞外捕网(neutrophil extracellular traps,NETs)是影响病情的重要机制之一.本文将综述NETs在ALI/ARDS病理生理过程中对肺血管内皮细胞、肺泡上皮细胞、凝血功能的影响及与免疫细胞的相互作用关系,并探讨靶向NETs治疗急性肺损伤策略及临床转化的挑战,旨在为该疾病诊疗提供新的思路.
Acute lung injury(ALI)/Acute respiratory distress syndrome(ARDS)is an inflammatory lung disease with high morbidity and mortality,and its diagnosis and treatment is still an important challenge worldwide.Neutrophil aggregation and infil-tration play a key role in the development of this disease,and it is currently believed that neutrophils release neutrophil extracellu-lar traps(NETs)as one of the important mechanisms affecting the disease.In this paper,we will review the effects of NETs on pulmonary vascular endothelial cells,alveolar epithelial cells,coagulation function and the interaction relationship with immune cells during the pathophysiological process of ALI/ARDS,and discuss the strategy of targeting NETs to treat acute lung injury and the challenges of clinical translation,with the aim of providing new ideas for the diagnosis and treatment of this disease.
张文星;唐雯;李政玉;鲁俊才;李兆;彭继超;姚津剑;刘笑然
海南医科大学急诊创伤学院,海南 海口 571199南华大学附属第一医院骨科中心,湖南 衡阳 421001海南医科大学急诊创伤学院,海南 海口 571199海南医科大学急诊创伤学院,海南 海口 571199海南医科大学急诊创伤学院,海南 海口 571199海南医科大学公共卫生学院,海南 海口 571199海南省人民医院/海南医科大学附属海南医院,海南 海口 570311海南医科大学急诊创伤学院,海南 海口 571199||海南医科大学急救与创伤研究教育部重点实验室,海南 海口 571199||海南医科大学第一附属医院,海南 海口 570102
医药卫生
中性粒细胞外捕网(NETs)急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)炎症免疫肺泡上皮细胞肺血管内皮细胞凝血
neutrophil extracellular traps(NETs)Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)In-flammationImmunityAlveolar epithelial cellsPulmonary vascular endothelial cellCoagulation
《海南医科大学学报》 2026 (6)
470-480,11
This study was supported by the National Natural Science Foundation of China(8196035182360379)Hainan Provincial Natural Science Foundation High-level Talent Project(822RC835) 国家自然科学基金(8196035182360379)海南省自然科学基金高层次人才项目(822RC835)
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