前梯度蛋白2和sTREM-1水平与慢性阻塞性肺疾病急性加重期肺部感染患者预后的关系OA

Objective To explore the relationship of anterior gradient 2(AGR2)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)with prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary infection.Methods A total of 168 AECOPD patients with pulmonary infection who were treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from October 2022 to January 2025 were prospectively selected as the infection group,and another 122 patients with AECOPD but without pulmonary infection who were matched for baseline data were included in the non-infection group.The general data and serum AGR2 and sTREM-1 levels were compared between the two groups,and the levels of serum AGR2 and sTREM-1 were compared among patients with different degrees of pulmonary infection.The predictive value of AGR2 and sTREM-1 levels on pulmonary infection in AECOPD patients was analyzed.The prognosis status was compared between both groups,and the levels of AGR2 and sTREM-1 in patients with different prognosis conditions were compared.Results The levels of AGR2 and sTREM-1[(25.31±4.40)ng/mL and(168.19±21.06)pg/mL]were significantly higher in the infection group than those in the non-infection group[(16.49±3.43)ng/mL and(149.42±16.83)pg/mL](t=19.162,8.429,P<0.001).The AGR2 and sTREM-1 levels in patients with mild infection,moderate infection and severe infection were increased successively(P<0.001).Receiver operating characteristic curve analysis revealed that the area under the curve of combined detection with AGR2 and sTREM-1 for pulmonary infection in AECOPD patients was 0.951.The good prognosis rate in the infection group[53.39%(98/165)]was significantly lower than the non-infection group[80.17%(97/121],P<0.001].Serum levels of AGR2(27.00±4.03 ng/mL)and sTREM-1(173.26±20.51 pg/mL)were significantly higher in patients with poor prognosis than in those with good prognosis[(24.53±4.28)ng/mL and(163.82±21.65)pg/mL,respectively;t=3.727,2.810,P<0.01].Conclusions Serum levels of AGR2 and sTREM-1 are significantly elevated in AECOPD patients with pulmonary infection and are associated with a poorer prognosis.Monitoring these biomarkers is of significant value for the assessment and management of such patients.