白花蛇舌草调控相关信号通路抗肿瘤的作用机制研究进展OA

The mechanisms of tumorigenesis involve the activation of oncogenes,inactivation of tumor suppressor genes,and abnormalities in apoptosis-regulating genes.Baihuasheshecao(Oldenlandia diffusa)can regulate multiple signaling pathways,including mitogen-acti-vated protein kinase(MAPK),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),Wnt/β-catenin,Janus kinase/signal transducer and activator of transcription(JAK/STAT),and nuclear factor-kappa B(NF-κB).Through these pathways,it inhibits tumor cell proliferation,modulates the cell cycle,suppresses migration and invasion,reverses immune escape,inhibits epithelial-mes-enchymal transition(EMT),regulates aerobic glycolysis metabolism and mitochondrial biogenesis,thereby promoting autophagy and ap-optosis of tumor cells,reducing tumor cell drug resistance,and modulating the tumor immune microenvironment.However,existing stud-ies mainly focus on animal experiments and in vitro cell levels,and clinical evidence is still insufficient.The optimal effective dosage re-mains to be clarified.In the future,the extraction and analysis of active components should be deepened,the dose-effect relationship should be clarified,and new regulatory mechanisms such as mitochondrial stress and ferroptosis should be explored to promote the pre-cise clinical application of Baihuasheshecao(Oldenlandia diffusa).