基于"气虚"理论探讨线粒体自噬与心力衰竭的关系OA

Heart failure,as the ultimate outcome of most cardiovascular diseases,is a syndrome caused by various factors leading to a de-cline in the heart's pumping ability,resulting in insufficient blood supply to the whole body.Mitophagy,as a means of mitochondrial quality control,primarily aims to specifically clear dysfunctional mitochondria within cells,thereby maintaining cellular homeostasis and allowing cells to perform their normal physiological functions.Modern research has found that dysfunction of mitophagy can also adverse-ly affect the routine function of cardiomyocytes,further impairing the normal physiological function of the heart.When mitophagy is de-fective,cardiomyocytes are further damaged.Traditional Chinese medicines that functions in warming Yang and boosting Qi can effec-tively increase mitophagy levels,improve mitochondrial quality,and maintain cardiomyocyte function.Moxibustion therapy and certain active components of Chinese medicine can also inhibit the sustained activation of cardiomyocyte mitophagy,preventing mitochondria from being excessively degraded and thus avoiding cardiac dysfunction.Future research needs to further explore the bidirectional regula-tory mechanism of traditional Chinese medicine on mitophagy,with the aim of identifying balance targets between mitophagy disorder and excessive autophagy,thereby achieving long-term maintenance of mitochondrial homeostasis in cardiomyocytes.