剪切波弹性成像及脉冲多普勒参数可有效鉴别乳腺癌分子亚型OA

Objective To investigate the association of maximum stiffness(Emax)measured by shear wave elastography(SWE)and the resistive index(RI)obtained by pulsed Doppler ultrasonography(PDU)with molecular subtypes of breast cancer.Methods A total of 137 patients with breast cancer(137 lesions)who underwent preoperative breast ultrasound and subsequent surgical resection from January 2024 to May 2025 were included.SWE parameters(Emax,Emin,and Emean),PDU-derived RI,and pathological data,including histological type,grade,hormone receptor status,HER-2 status,and Ki-67 proliferation index,were analyzed.Univariate analysis and multiple linear regression were performed to evaluate the relationship between imaging parameters and pathological findings.Results Among the 137 lesions,invasive ductal carcinoma was the most common histological type,and Luminal A type was the predominant molecular subtype.Triple-negative type(TNBC)lesions exhibited significantly higher Emax values compared to Luminal A type,Luminal B type,and HER-2-positive type.The highest RI values were observed in TNBC,followed by HER-2-positive,Luminal B,and Luminal A subtypes.Multiple linear regression analysis indicated that tumor size,histological grade,and molecular subtype were independent predictors of both Emax and RI(P<0.05).Conclusion Increased tumor stiffness and higher resistive index may be associated with aggressive histopathological features in breast cancer.Softer tumors tend to correlate with the Luminal A subtype,whereas stiffer tumors are more likely to be TNBC.