呼吸道合胞病毒肺炎新生儿恢复期潮气肺功能特征分析OA
Analysis of tidal lung function characteristics in the recovery period of neonates with respiratory syncytial virus pneumonia
目的 探讨呼吸道合胞病毒(respiratory syncytial virus,RSV)肺炎新生儿恢复期潮气肺功能特点.方法 采用回顾性研究方法,选取 2023 年 11 月至 2024 年 2 月电子科技大学医学院附属妇女儿童医院收治的 96 例社区获得性肺炎新生儿,根据入院 48 h内痰液核酸检测结果,分为RSV肺炎组(n=48)和非RSV肺炎组(n=48),RSV肺炎患儿分为早产儿和足月儿,RSV肺炎早产儿分为合并支气管肺发育不良(bronchopulmonary dysplasia)组和未患BPD组.对比组间肺炎新生儿恢复期的潮气肺功能检测结果.统计学方法采用t检验、χ2 检验.结果 RSV肺炎组的达峰时间比(time to peak tidal expiratory flow/total expiratory time,tPEF/tE)和达峰容积比(volume to peak expiratory flow/expired tidal volume,VPEF/Vt)均低于非RSV肺炎组[(33.79±10.58)%与(39.29±10.79)%,(33.97±8.88)%与(38.60±9.71)%,P值均<0.05];RSV肺炎组中,早产儿的tPEF/tE、VPEF/Vt均低于足月儿[(24.99±6.15)%与(32.31±8.83)%,(26.99±5.64)%与(32.28±7.86)%,P值均<0.05];与未患BPD的RSV肺炎早产儿相比,合并BPD的RSV肺炎早产儿恢复期的tPEF/tE、VPEF/Vt显著降低[(27.16±1.64)%与(20.30±2.66)%,(28.64±5.78)%与(23.42±2.01)%,P均值<0.05].结论 RSV肺炎新生儿,尤其是早产儿、BPD患儿在恢复期存在阻塞性通气功能障碍的风险高于非RSV肺炎新生儿;临床医师应加强对RSV肺炎新生儿,特别是早产儿及合并BPD患儿进行肺功能检测和长期随访.
Objective To explore the tidal lung function characteristics in the recovery period of neonates with respiratory syncytial virus pneumonia.Method A retrospective study was conducted on 96 neonates with community-acquired pneumonia who were admitted to the Affiliated Women's and Children's Hospital,School of Medicine,University of Electronic Science and Technology of China from November 2023 to February 2024.Based on the results of sputum nucleic acid testing within 48 h of admission,they were divided into RSV pneumonia group(n=48)and non-RSV pneumonia group(n=48).Children with RSV pneumonia were divided into preterm and full-term infants.Preterm infants with RSV pneumonia were further categorized into those with bronchopulmonary dysplasia(BPD)and those without BPD.The results of tidal lung function detection of the groups were compared during the recovery period.Statistical analysis was performed using the independent samples t-test and χ2 test.Results The time to peak tidal expiratory flow/total expiratory time(tPEF/tE)and volume to peak expiratory flow/expired tidal volume(VPEF/Vt)in the RSV pneumonia group were lower than those in the non-RSV pneumonia group[(33.79±10.58)%vs(39.29±10.79)%,(33.97±8.88)%vs(38.60±9.71)%,respectively;all P<0.05].In the RSV pneumonia group,the tPEF/tE and VPEF/Vt in preterm infants were lower than those in full-term infants[(24.99±6.15)%vs(32.31±8.83)%,(26.99±5.64)%vs(32.28±7.86)%,all P<0.05].Additionally,compared with preterm infants without BPD,the tPEF/tE and VPEF/Vt of preterm infants with RSV pneumonia and BPD during the recovery period were significantly lower[(27.16±1.64)%vs(20.30±2.66)%,(28.64±5.78)%vs(23.42±2.01)%,all P<0.05].Conclusion Neonates with RSV pneumonia,particularly preterm infants and those with BPD,face an increased likelihood of obstructive ventilatory dysfunction during the recovery period compared to neonates with non-RSV pneumonia.Clinicians should reinforce pulmonary function testing and long-term follow-up for neonates with RSV pneumonia,especially for preterm infants and children with BPD.
杜维纳;高淑强;张小龙;林利苹;巨容
电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院 新生儿科,四川 成都 611731电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院 新生儿科,四川 成都 611731电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院 新生儿科,四川 成都 611731电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院 新生儿科,四川 成都 611731电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院 新生儿科,四川 成都 611731
呼吸道合胞病毒新生儿肺炎肺功能气道阻力
Respiratory syncytial virusNeonatePneumoniaLung functionAirway resistance
《发育医学电子杂志》 2026 (2)
95-101,7
四川省科技计划项目(2022YFS0241)
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