中老年人群握力和甘油三酯-葡萄糖指数与全因死亡率的联合关联性分析OA

Objective:To explore the joint association between grip strength and triglyceride glucose(TyG)index with all cause mortality among middle aged and elderly people aged 45 and above in China,and to provide a scientific basis for health management and preventive intervention strategies for this population.Methods:A total of 8 392 middle aged and elderly people aged 45 and above from the China Health and Retirement Longitudinal Study(CHARLS)database from 2011 to 2020 were selected.They were divided into a survival group(n=7 348)and a death group(n=1 028)according to whether they died during the follow up period.Three model corrections were carried out according to age,gender,educational level,marital status,etc.Cox regression was used to analyze the joint association between grip strength,TyG index and all cause mortality risk.Results:Decreased grip strength and increased TyG index could significantly increase the risk of all cause mortality.In Model 3,compared with those with normal grip strength,the hazard ratio(HR)of those with decreased grip strength was 1.84(95％CI:1.61,2.10).Compared with those with low TyG,the HR of those with high TyG was 1.24(95％CI:1.07,1.44).Among those with low TyG,compared with those with normal grip strength,the HR of those with decreased grip strength was 1.76(95％CI:1.45,2.13).Among those with high TyG,compared with those with normal grip strength,the HR of those with decreased grip strength was 1.87(95％CI:1.55,2.26).Compared with those with normal grip strength-low TyG,the HRs of those with normal grip strength-high TyG,decreased grip strength-low TyG and decreased grip strength-high TyG were 1.23(95％CI:1.02,1.48),1.85(95％CI:1.54,2.22)and 2.24(95％CI:1.83,2.73),respectively.Conclusion:Decreased grip strength and increased TyG index significantly increase the mortality risk of middle aged and elderly people.