代谢失衡:从分子机制到多系统疾病干预的研究新范式OA

Metabolic imbalance,as a core issue of modern medicine,drives the occurrence of multi-system diseases by disrupting the homeostasis of material and energy metabolism.This article systematically integrates the latest research,revealing that metabolic imbalance forms a bidirectional regulatory network with diseases such as cerebral infarction,chronic kidney disease,and diabetes through pathways like insulin resistance,inflammatory cascades,and oxidative stress.Current research focuses on the analysis of molecular mechanisms and the development of individualized intervention strategies,but breakthroughs are still needed in areas such as individual heterogeneity and the interaction between microbiota and metabolism.This review aims to construct a comprehensive cognitive framework of"metabolic imbalance-disease occurrence-precise management",providing a theoretical basis for clinical translation.