中医脾胃病脑肠互动原理的基础研究现状、问题及策略OA

The brain-gut interaction theory is a multidimensional integrative concept based on the brain-gut axis,involving neural,endocrine,and immune regulatory networks as well as the gut microbiota.Zangfu organs(脏腑)theory in traditional Chinese medicine(TCM)shows a high degree of consistency with the brain-gut interaction theory,and the core functions such as the spleen and stomach governing the ascending of the clear and descending of the turbid,the liver governing the free flow of qi,and the heart governing mental and emotional activities are closely asso-ciated with the multi-level regulatory mechanisms of the brain-gut axis.TCM therapy can modulate brain-gut interac-tions through multiple pathways in the treatment of spleen and stomach diseases,including the regulation of gastroin-testinal hormone secretion,neurotransmitter levels,the hypothalamic-pituitary-adrenal(HPA)axis,immune homeo-stasis and inflammatory responses,as well as the gut microecology.However,current basic research on the brain-gut interaction theory in TCM for spleen and stomach diseases still faces several challenges,such as difficulties in inte-grating TCM spleen-stomach theory with modern pathophysiology,lack of innovation in research concepts,and limita-tions in research methodologies.It is therefore proposed that multidisciplinary collaboration,multi-omics technologies,and targeted research approaches should be adopted to provide more comprehensive methods for basic research on TCM spleen and stomach diseases,thereby promoting the in-depth development of brain-gut interaction theory.