中医脾胃病证候与病证结合动物模型研究现状及展望OA

Animal model research on spleen and stomach diseases in traditional Chinese medicine(TCM)is of great significance for elucidating the nature of diseases and syndromes and for revealing the mechanisms of action of Chinese herbal medicinals.At present,studies on classical TCM syndrome models of spleen and stomach diseases mainly focus on spleen deficiency syndrome,liver constraint syndrome,and damp-heat syndrome.Model construc-tion is mostly based on the etiological and pathophysiological characteristics of syndrome,and model evaluation primarily involves macroscopic manifestations and physicochemical indicators.This paper summarizes the current research status of animal models integrating disease and syndrome for seven common spleen and stomach diseases,including chronic gastritis and gastric precancerous lesions,gastroesophageal reflux disease,functional dyspepsia,inflammatory bowel disease,irritable bowel syndrome,functional constipation,and functional diarrhea.The model-ing methods and characteristics of disease-syndrome combined animal models for each disease are analyzed.It is pro-posed that future research on disease-syndrome integration in spleen and stomach diseases should move toward syste-matic,precise,and integrative development,and that interdisciplinary and cross-disciplinary research approaches should be adopted to enhance the predictive value and application efficiency of disease-syndrome combined animal models.