从"痰毒流注"理论探析进展期胃癌的中医病机演变与转移机制OA

This article systematically explores the traditional Chinese medicine(TCM)pathogenesis evolution and metastatic mechanisms of advanced gastric cancer from the perspective of"phlegm-toxin flowing infusion".Based on this theory,it is proposed that advanced gastric cancer presents a pathogenesis evolution characterized by healthy qi depletion,phlegm-toxin flowing infusion,and collateral damage with blood stasis.Healthy qi depletion is the root of the disease,in which spleen and kidney insufficiency leads to weakened healthy qi and inability to resist patho-genic factors.Phlegm-toxin flowing infusion is the core pathogenesis,where phlegm-dampness and cancer toxin inter-twine and migrate to other organs along with qi movement.Collateral damage with blood stasis constitutes the final pathological stage of metastasis,where phlegm-toxin obstruction damages the collaterals,and congealed qi and blood form accumulations.On this basis,the meridian pathways and metastasis mechanisms of advanced gastric can-cer spreading to multiple sites such as the liver,peritoneum,lungs,bones,brain,ovary,and lymph nodes are further analyzed,providing references for clinical management and research of this disease.