王晞星从"五脏致咳"辨治免疫检查点抑制剂相关性肺炎经验OA

This paper summarizes Professor WANG Xixing's clinical experience in treating immune checkpoint inhibitor-related pneumonitis(CIP)based on the theory of"cough attributed to the five zang(脏)organs".Cough is a common predominant symptom of CIP.According to the theory of"cough attributed to the five zang organs",drug toxicity triggers cancer toxin,leading to disharmony among the five zang organs,and then lung failing to diffuse and govern descent as the core pathogenesis.Therefore,treatment should focus on harmonizing the five zang organs to restore the normal function of lung qi to diffuse and govern descent.In clinical practice,CIP can be classified into four syn-drome patterns,including lung yin depletion,deficiency of both the lung and the spleen with phlegm-dampness,liver fire harassing the lung,and lung-kidney yin deficiency.Correspondingly,Chaimai Jinluo Runfei Decoction(柴麦金络润肺汤)is used to nourish yin and moisten the lung;Qigui Peitu Huayin Decoction(芪桂培土化饮汤)is used to fortify the spleen and tonify the lung,resolve dampness and dispel phlegm;Chaidan Shuyu Runjin Decoction(柴丹疏郁润金汤)is used to drain liver and clear the lung;and Dimai Jinshui Xiangsheng Decoction(地脉金水相生汤)is used to nourish the kidney and moisten the lung.