代谢组学及其新技术在中医药诊疗慢性气道炎症性疾病中的应用进展OA

Chronic airway inflammatory diseases refer to chronic respiratory disorders caused by infections or allergic reactions,involving airway-resident cells,inflammatory cells,and various cytokines.These diseases mainly include chronic obstructive pulmonary disease and bronchial asthma.Their etiology and pathogenesis are complex and remain incompletely understood,posing numerous challenges for clinical diagnosis and treatment.TCM has demonstrated significant advantages in the diagnosis and treatment of chronic airway inflammatory diseases,yet its mechanisms of action and therapeutic efficacy urgently require elucidation through modern technologies.Metabolomics,as an important branch of systems biology,enables comprehensive analysis of metabolic networks within organisms.Characterized by its holistic,systemic,and integrative nature,it aligns well with the holistic concepts and syndrome differentiation principles of TCM.Metabolomics plays an important role in identifying syndrome-specific biomarkers and enhancing the diagnosis and treatment of diseases,and it has now been widely applied in research on chronic airway inflammatory diseases.Furthermore,advances in frontier technologies such as single-cell metabolomics and spatial metabolomics have overcome the limitations of traditional metabolomics.These technologies enable precise analysis and detection at the single-cell level,as well as in situ spatial localization of metabolites within tissues,thereby providing new methodological support for elucidating the complex mechanisms of TCM.Using chronic obstructive pulmonary disease and bronchial asthma as representative conditions,this review systematically summarizes the application of metabolomics and its integration with multi-omics approaches in the TCM-based diagnosis and treatment of chronic airway inflammatory diseases over the past decade.It also explores the prospects of these emerging technologies in this field,with the aim of providing a theoretical foundation for TCM diagnosis and treatment of chronic airway inflammatory diseases and offering new perspectives for the modernization of TCM research.