中药纳米科学:方剂纳米体原理与中药先进治疗制剂OA

As a frontier field integrating traditional Chinese medicine(TCM)theory with modern nanotechnology,traditional Chinese medicine nanoscience(TCMN)is spearheading revolutionary breakthroughs in the modernization of TCM.Innovative breakthroughs in TCM nanoscience are mainly reflected in the formula-derived nanoparticles of TCM(FDN)and the formula-derived nanoparticles drug discovery(FDD),intelligent delivery of multi-active components in TCM,precision design of nanocarrier systems,and technological innovations through multidisciplinary integration.TCMN transforms the"dark knowledge"of formula combinations into quantifiable and controllable"explicit knowledge",enabling scientific interpretation of the complex systems within TCM at the nanoscale.The formation and development of the TCMN and the principles of formula-derived nanoparticles will greatly advance the interpretation of TCM principles and their therapeutic advantages:clarifying clearly material basis(discovery of novel micro-and nano-scale active substances),elucidating the mechanism of action(multi-level dynamic network regulatory mechanism),developing innovative drugs(multi-target advanced therapy medicinal products based on TCM),and inheriting the essence(enhancing its therapeutic advantages of TCM).The future development of TCMN will exhibit distinct characteristics of in-depth multidisciplinary integration,technological paradigm innovation,and industrial ecosystem reconstruction.It is not only expected to break through the technical bottlenecks and regulatory issues currently faced by advanced therapy medicinal products of TCM,but also create a brand-new model for TCM in treating complex diseases.Furthermore,it will play an increasingly important role in treating major diseases and safeguarding human health,opening up unprecedented broad prospects for the inheritance,innovation,and international development of TCM.