山楂中有效成分及其治疗非酒精性脂肪肝的作用机制研究进展OA

Objective:To systematically summarizes the primary active constituents in Cratargi Fructus and their mechanism of action in the treatment of non-alcoholic fatty liver disease(NAFLD),aiming to provide a reference for the clinical application,in-depth research,and development and utilization of Cratargi Fructus for the treatment of NAFLD.Methods:This study employed a systematic literature review method,utilizing keywords such as"Cratargi Fructus"and"nonalcoholic fatty liver disease",to conduct searches in domestic and international databases including CNKI,Web of Science,and PubMed.It comprehensively reviews the research progress on the active constituents of Cratargi Fructus and their mechanisms of action in treating NAFLD in recent years.Results and Conclusion:Cratargi Fructus is rich in active constituents such as flavonoids,organic acids,triterpenes,and polysaccharides.It can reduce hepatic fat deposi-tion,inhibit lipid peroxidation,alleviate hepatic inflammation injury,and prevent liver fibrosis through multiple pathways.These include regulating lipid metabolism,exerting antioxidant and anti-inflammatory effects,modulating the gut microbiota,and providing anti-fibrotic effects.The characteristic multi-component,multi-target,and multi-pathway regulatory profile of Cratargi Fructus demonstrates unique potential in the and treatment of NAFLD.