爆震性聋的发病机制及潜在生物标志物研究进展OA

Explosive Deafness is an acute damage to the auditory system caused by explosive shock waves or high-intensity impulse noise.It is a common occupational disease in troops,mining and blasting workers.Epidemiological data show that with the improvement of military training intensity and the acceleration of industrialization,the incidence rate continues to rise.The damage mechanism of this disease is complex.In addition to the mechanical damage of the outer ear/middle ear(such as tympanic membrane perforation,ossicular chain dislocation)directly caused by the shock wave,it can also induce metabolic cascade damage to the inner ear,including oxidative stress,cochlear blood flow reduction,calcium overload and cochlear nerve damage.Recent studies have confirmed that biomarkers have a key value in revealing the dynamic pathological process of explosive deafness,achieving early diagnosis and prognosis evaluation.This paper is to review the research progress of biomarkers of explosive deafness,and to provide some new ideas for the prevention and treatment of explosive deafness in clinical practice.