短期低热量饮食干预中健康成人的血脂波动模式:一项初步研究OA

[Objective]To investigate the effects of a 14-day strictly controlled low-calorie diet intervention on the dynamic changes in blood lipid profiles of healthy adults.[Method]A total of 25 healthy adult subjects were recruited and underwent a 14-day standardized low-calorie diet intervention.Centralized meal provision and on-site supervision were implemented to ensure compliance.Fasting venous blood was collected at baseline and multiple time points after intervention to measure total cholesterol,triglycerides,high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol levels,and their dynamic changes were analyzed.[Result]In the early intervention phase(days 1-3),total cholesterol,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol levels transiently increased,while triglycerides decreased significantly.In the mid-to-late intervention phase(days 4-14),total cholesterol,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol levels all declined significantly,while triglycerides continued to decrease.Body weight decreased significantly,but no statistically significant change was observed in body fat percentage.[Conclusion]Short-term low-calorie diet intervention can induce a biphasic fluctuation pattern in blood lipid profiles of healthy adults,characterized by an initial increase followed by a decrease,suggesting that the assessment of dietary intervention effects should consider the temporal changes in blood lipid parameters.