黄芩主要活性成分对非酒精性脂肪肝保护作用机制的研究进展OA
Research Progress on Protective Mechanism of The Main Active Ingredients of Scutellaria baicalensis on Non-Alcoholic Fatty Liver Disease
目的:了解黄芩对非酒精性脂肪肝的保护作用及机制.方法:通过对国内外相关文献进行整理和汇总,从肝脏脂质代谢途径、氧化应激、炎症通路、细胞铁死亡途径等多方面综述了其防治非酒精性脂肪肝的可能机制.结果:黄芩素和黄芩苷及中药汤剂治疗NAFLD的机制可能与调节脂质代谢、调节氧化应激、调节炎症反应等多种途径相关.虽然有大量的基础实验研究证明其功效,但是缺少人群实验来进行验证,同时其转化应用的研究存在一定的不足.结论:本综述可为黄芩的开发利用及其在临床应用治疗非酒精性脂肪肝提供科学依据.
[Objective]To further understand the protective effect and mechanism of Scutellaria baicalensis on non-alcoholic fatty liver disease.[Method]This paper summarized the relevant literature at home and abroad,and comprehensively expounded the possible mechanism of its prevention and treatment of non-alcoholic fatty liver disease from the aspects of liver lipid metabolism pathway,oxidative stress,inflammatory pathway,and cell ferroptosis pathway.[Result]The mechanism of baicalein,baicalin,and traditional Chinese medicine decoc-tion in treating NAFLD may be related to various pathways such as regulating lipid metabolism,oxidative stress,and inflammatory response.Although there is a large amount of basic experimental research to prove its effectiveness,there is a lack of population experiments to verify it,and there are certain shortcomings in the research on its translational applications.[Conclusion]It provides a scientific basis for the development and utilization of Scutellaria baicalensis for clinical application in the treatment of non-alcoholic fatty liver disease.
胡丽艳;安艳新;单婕;吕佳宁;高晓红;尤佳伟;陈琳
西安医学院第一附属医院临床营养科,西安 710077西安医学院第一附属医院临床营养科,西安 710077西安医学院第一附属医院临床营养科,西安 710077西安医学院第一附属医院临床营养科,西安 710077西安医学院第一附属医院临床营养科,西安 710077西安医学院第一附属医院临床营养科,西安 710077西安医学院第一附属医院临床营养科,西安 710077
黄芩非酒精性脂肪性肝病作用机制脂质代谢
Scutellaria baicalensisnonalcoholic fatty liver disease(NAFLD)action mechanismlipid metabolism
《中国食物与营养》 2026 (3)
59-63,5
陕西省卫生健康委员会面上项目(项目编号:2022D042).
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