西部少数民族地区HIV感染合并肺结核患者预后的临床与社会学分析OA
Clinical and sociological analysis of patients with human immunodeficiency virus infection complicated with pulmonary tuberculosis in western ethnic minority area
目的 探讨西部少数民族地区人类免疫缺陷病毒(HIV)感染合并肺结核患者的临床及社会学特征,分析影响其预后的危险因素,为资源有限地区制定综合防控与干预策略提供依据.方法 回顾性纳入2022年1月—2023年12月西部某少数民族地区人民医院收治的126例 HIV感染合并肺结核患者,收集其人口学、临床、实验室、影像学及社会学资料(教育水平、婚姻状况、交通可及性、经济状况),比较预后良好组与预后不良组的差异,并采用多因素logistic回归分析其预后的独立危险因素.结果 126例患者中,男性占77.0%,平均年龄(40.3±9.2)岁.多因素logistic回归分析表明,CD4+T淋巴细胞<200个/μL(OR=8.59,95%CI:3.31～22.29)、双侧肺病变(OR=6.23,95%CI:2.57～15.07)、不规范抗结核治疗(OR=5.89,95%CI:2.62～13.22)以及低教育水平(OR=3.65,95%CI:1.54～8.65)为预后不良的独立危险因素.结论 HIV感染合并肺结核患者预后不仅受临床因素影响,还与社会学特征密切相关.改善治疗依从性、强化社区支持及提升健康教育水平,对改善边远少数民族地区HIV感染合并肺结核患者的预后具有重要意义.
Objective To explore the clinical and sociological characteristics of patients with human immunodefi-ciency virus(HIV)infection complicated with pulmonary tuberculosis(PTB)in western ethnic minority area,analyze the risk factors affecting their prognosis,and provide basis for developing comprehensive prevention and intervention strategies in resource-limited areas.Methods 126 patients with HIV-PTB co-infection admitted to a people's hospital in a western ethnic minority area from January 2022 to December 2023 were included in analysis retrospectively.Demographic,clinical,laboratory,imaging,and sociological data(education level,marital status,transportation accessibility,economic status)of patients were collected,and the differences between good prognosis group and poor prognosis group were compared,independent risk factors for the prognosis were analyzed by multi-variate logistic regression.Results Among the 126 patients,77.0%were male,with an average age of(40.3±9.2)years old.Multivariate logistic regression analysis showed that CD4+T lymphocyte cells<200 cells/μL(OR=8.59,95%CI:3.31-22.29),bilateral lung lesions(OR=6.23,95%CI:2.57-15.07),non-standard anti-tuberculosis treatment(OR=5.89,95%CI:2.62-13.22),and low education level(OR=3.65,95%CI:1.54-8.65)were independent risk factors for poor prognosis.Conclusion The prognosis of patients with HIV-PTB co-infection is not only affected by clinical factors,but also closely related to sociological characteristics.Improving treatment compliance,strengthening community support,and enhancing health education levels are of great signifi-cance for improving the prognosis of patients with HIV-PTB co-infection in remote ethnic minority area.
雷俊杰;沈小英;李昌敏;吉以也布;胡攀志;杨发平;何浩岚;刘新华
四川省凉山彝族自治州昭觉县人民医院感染科,四川 凉山 615000四川省凉山彝族自治州昭觉县人民医院感染科,四川 凉山 615000四川省凉山彝族自治州昭觉县人民医院感染科,四川 凉山 615000四川省凉山彝族自治州昭觉县人民医院感染科,四川 凉山 615000四川省凉山彝族自治州昭觉县人民医院感染科,四川 凉山 615000四川省凉山彝族自治州昭觉县人民医院感染科,四川 凉山 615000广州医科大学附属市八医院感染病中心,广东 广州 510440广州医科大学附属市八医院感染病中心,广东 广州 510440
医药卫生
HIVAIDS结核病双重感染预后社会学因素少数民族地区
HIVAIDStuberculosisdual infectionprognosissociological factorethnic minority area
《中国感染控制杂志》 2026 (3)
352-356,5
广州市科技计划项目(2024A03J0874)中国性病艾滋病防治协会凉山州"三线一网底"能力建设开放式小额资助项目(LS2024OR03)
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