成功使用白介素-6抗体托珠单抗控制肺腺癌顽固性肿瘤热1例病例报道OA

Fever is a common symptom of lung cancer,but most are induced by infection.This is the first report of a patient with lung adenocarcinoma who developed a fever of unknown origin for more than 1 month after repeat biopsy on the progression of first-line treatment in China.Comprehensive blood tests,the well-known pathogens were fully examined,and imaging studies failed to support infectious fever,connective tissue disease-related fever,drug fever,or other etiologies,lead-ing to the diagnosis of tumor fever.While the fever remained refractory to Ibuprofen,it was successfully controlled 12 h after a single intravenous administration of Tocilizumab,with the patient maintaining a normal body temperature for 45 days,from August 21 to October 4,2025.This case report primarily provides the practice for exploring the tumor fever.