非小细胞肺癌淋巴结结外侵犯的临床意义:研究现状与展望OA
Clinical Significance of Extranodal Extension in Non-small Cell Lung Cancer:Current Status and Future Prospects
2022年全球癌症数据显示,肺癌位居全球癌症发病率及死亡率首位,而淋巴结转移是评估其预后及指导治疗的关键环节.淋巴结结外侵犯(extranodal extension,ENE)是指肿瘤细胞突破淋巴结被膜、侵犯周围组织的病理现象,在非小细胞肺癌(non-small cell lung cancer,NSCLC)中,尽管ENE尚未被正式纳入肿瘤原发灶-淋巴结-转移(tumor-node-metastasis,TNM)分期系统,但其临床价值已受到广泛关注.本文系统梳理ENE在NSCLC中的定义、诊断方法、预后意义及治疗相关研究进展,分析当前研究困境并提出未来展望.本文旨在为临床实践优化与后续研究开展提供参考.
Global cancer statistics in 2022 ranked lung cancer as the leading cause of cancer incidence and mortality worldwide,with lymph node metastasis serving as a pivotal determinant of prognosis and treatment strategy.Extranodal exten-sion(ENE)refers to the pathological phenomenon where tumor cells breach the lymph node capsule and invade surrounding tissues.In non-small cell lung cancer(NSCLC),although ENE has not yet been formally incorporated into the tumor-node-metastasis(TNM)staging system,its clinical value is gaining increasing attention.This review systematically summarizes the current research progress regarding the definition,diagnostic approaches,prognostic significance,and treatment implications of ENE in NSCLC,analyzes existing challenges,and proposes future directions.The goal of this paper is to provide insights for optimizing clinical practice and guiding subsequent research.
梁韩;孟娅洁;王琪;李才繁;杨昊;向旭东
650100 昆明,昆明医科大学第三附属医院,云南省肿瘤医院,北京大学肿瘤医院云南医院胸外二科650100 昆明,昆明医科大学第三附属医院,云南省肿瘤医院,北京大学肿瘤医院云南医院乳腺外科二病区650100 昆明,昆明医科大学第三附属医院,云南省肿瘤医院,北京大学肿瘤医院云南医院胸外二科650100 昆明,昆明医科大学第三附属医院,云南省肿瘤医院,北京大学肿瘤医院云南医院胸外二科650100 昆明,昆明医科大学第三附属医院,云南省肿瘤医院,北京大学肿瘤医院云南医院胸外二科650100 昆明,昆明医科大学第三附属医院,云南省肿瘤医院,北京大学肿瘤医院云南医院胸外二科
肺肿瘤结外侵犯残留肿瘤预后
Lung neoplasmsExtranodal extensionResidual neoplasmPrognosis
《中国肺癌杂志》 2026 (1)
47-58,12
This paper was supported by the grants from 2025 Degree and Graduate Education Innovation Fund Project of Kun-ming Medical University(No.2025S109,to Han LIANGNo.2025S271,to Yajie MENG). 本文受昆明医科大学2025年学位与研究生教育创新基金项目(No.2025S109,No.2025S271)资助
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