早产儿支气管肺发育不良相关肺动脉高压危险因素的Meta分析OA

Objective To systematically evaluate the incidence and risk factors of pulmonary hypertension(PH)associated with bronchopulmonary dysplasia(BPD)in preterm infants.Methods Cohort and case-control studies on the incidence and risk factors of PH complicating BPD(hereinafter referred to as BPD-PH)in preterm infants,published from database inception to July 2024,were retrieved from China National Knowledge Infrastructure,Wanfang Data,VIP Database,Chinese Biomedical Literature Database,PubMed,Web of Science,Embase,MEDLINE,and Cochrane Library.Meta analysis was performed using Stata 15.0 software.Results A total of 15 studies involving 4 561 preterm infants were included.Meta analysis results showed that the overall incidence of BPD-PH in preterm infants was 20.1%(95%CI:16.1%-24.0%).Hemodynamically significant patent ductus arteriosus(OR=3.43),mechanical ventilation duration(OR=1.05),small for gestational age(SGA)(OR=7.30),severe BPD(OR=13.25),patent ductus arteriosus requiring surgical ligation(OR=6.03),oligohydramnios(OR=7.24),ventilator-associated pneumonia(OR=3.97),and respiratory distress syndrome(OR=2.70)were identified as risk factors for BPD-PH in preterm infants(P<0.05).Conclusions The overall incidence of BPD-PH in preterm infants is relatively high.Hemodynamically significant patent ductus arteriosus,mechanical ventilation duration,SGA,severe BPD,patent ductus arteriosus requiring surgical ligation,oligohydramnios,ventilator-associated pneumonia,and respiratory distress syndrome can increase the risk of PH in preterm infants with BPD,and clinical monitoring should prioritize BPD infants with these high-risk factors.